Search results for " TYR"
showing 10 items of 362 documents
VIZUALINIS MOKTYTOJO ĮVAIZDIS: LYGINAMASIS TYRIMAS
2013
Dr. paed., Instituteof Educational Sciences, University of Latvia, Latvia. E-mail: iveta.kestere@lu.lv Address: Laimdotas 37, Rīga LV1006, Latvia Phone +371 29496660; +32 473 63 37 98PhD, Graduate School of Education, North West University, South Africa. E-mail: Charl.Wolhuter@nwu.ac.za Address: North-West University, Private Bag X 6001, Potchefstroom 2520, South AfricaPhD, Educational Sciences Department, Yeditepe University, Turkey. E-mail: ricardolozanov@gmail.comStraipsnyje „Vizualinis mokytojo įvaizdis: lyginamasis tyrimas“ pateikiami tyrimo, atlikto dešimtyje šalių – Anglijoje, Pietų Afrikoje, Serbijoje, Slovėnijoje, Graikijoje, Bulgarijoje, Latvijoje, Turkijoje, Pakistane ir Meksi…
FGFR a promising druggable target in cancer: Molecular biology and new drugs.
2017
Abstract: Introduction: The Fibroblast Growth Factor Receptor (FGFR) family consists of Tyrosine Kinase Receptors (TKR) involved in several biological functions. Recently, alterations of FGFR have been reported to be important for progression and development of several cancers. In this setting, different studies are trying to evaluate the efficacy of different therapies targeting FGFR. Areas Covered: This review summarizes the current status of treatments targeting FGFR, focusing on the trials that are evaluating the FGFR profile as inclusion criteria: Multi-Target, Pan-FGFR Inhibitors and anti-FGF (Fibroblast Growth Factor)/FGFR Monoclonal Antibodies. Expert opinion: Most of the TKR share …
De novo design of protein kinase inhibitors by in silico identification of hinge region-binding fragments.
2013
Protein kinases constitute an attractive family of enzyme targets with high relevance to cell and disease biology. Small molecule inhibitors are powerful tools to dissect and elucidate the function of kinases in chemical biology research and to serve as potential starting points for drug discovery. However, the discovery and development of novel inhibitors remains challenging. Here, we describe a structure-based de novo design approach that generates novel, hinge-binding fragments that are synthetically feasible and can be elaborated to small molecule libraries. Starting from commercially available compounds, core fragments were extracted, filtered for pharmacophoric properties compatible w…
Serve ancora ucidere i tiranni? A proposito di Ps. Quint. decl. min. 253
2018
The paper deals with Ps. Quint. decl. min. 253; in the text, concerning one of the best-known themes of the declamatory literature, a tyrannicide, after killing a tyrant, asks the community for approval of a rogatio in order to be sent to the tyrant of the nearby city. The declamation focuses on a hero willing to put the salvation of the community before his own, a theme certainly usual in Latin thought, but which traces new interpretative ways in the declamatory culture.
Mutations and Deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascades Which Alter Therapy Response.
2012
The Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades are often activated by genetic alterations in upstream signaling molecules such as receptor tyrosine kinases (RTK). Certain components of these pathways, RAS, NF1, BRAF, MEK1, DUSP5, PP2A, PIK3CA, PIK3R1, PIK3R4, PIK3R5, IRS4, AKT, NFKB1, MTOR, PTEN, TSC1, and TSC2 may also be activated/inactivated by mutations or epigenetic silencing. Upstream mutations in one signaling pathway or even in downstream components of the same pathway can alter the sensitivity of the cells to certain small molecule inhibitors. These pathways have profound effects on proliferative, apoptotic and differentiation pathways. Dysregulation of components of these cas…
Maitrise de la fermentation butyrique par la microflore lactique réductrice
2018
Clostridium tyrobutyricum, bactérie anaérobie stricte, endosporulée, est à l’origine de l’apparition du défaut appelé «gonflement tardif » lors de l’étape d’affinage de nombreux fromages à pâtes pressées non cuites et cuites. Selon d’Incecco et al. (2018), elle passerait de l’état spore à un état de cellule végétative à la fin de l’étape d’acidification. Par ailleurs dans le projet ANR FoodREDOX, il a été montré qu’un ensemencement dans le lait d’une microflore abaissant le potentiel d’oxydoréduction, ralentirait la consommation de lactates et la production de butyrate par C. tyrobutyricum lors de l’affinage des fromages. Ainsi, connaître et comprendre les mécanismes de germination, sporula…
Biogeochemical evaluation of historical sediment contamination in the Gulf of Palermo (NW Sicily): Analysis of pseudotrace elements and stable isotop…
2012
Abstract Sedimentary biogeochemical data from the Gulf of Palermo, which borders one of the major urban and industrial areas of the central Mediterranean, provide a decennial–centennial-scale record of the effects of human activity on this coastal environment. In this study we report trace elements (TE), C org /N tot ratios, δ 13 C org , and δ 15 N tot from dated ( 210 Pb) sediments collected in two coastal stations variably influenced by urban/fluvial loadings and illegal dumping and we compare them with published data for offshore sediments, in order to investigate at a large spatial scale the influence of on-land activities on sedimentary marine system. TE were generally low except for H…
Toward more realistic viscosity measurements of tyre rubber–bitumen blends
2014
AbstractThe measurement of rheological properties of the tyre rubber bitumen blends is often challenging due to presence of suspended tyre rubber’s crumbs. Furthermore, the phase separation during the course of measurements makes the viscosity of these non-homogeneous blends difficult to ascertain. In this study, a new dual helical impeller was designed and manufactured to be used with a rotational viscometer in order to have a real-time control of the viscosity while performing a laboratory mixing of the blends. Layer based manufacturing techniques showed to be a convenient method to produce complex shaped impeller prototypes before manufacturing the more expensive stainless steel assembly…
Prenatal Clinical Assessment of sFlt-1 (Soluble fms-like Tyrosine Kinase-1)/PlGF (Placental Growth Factor) Ratio as a Diagnostic Tool for Preeclampsi…
2013
Background: Aim of the study was a critical assessment of the clinical validity of the prenatal determination of sFlt-1/PlGF for preeclampsia (PE), pregnancy-induced hypertension (PIH), and proteinuria. Our analysis was based on a specificity of 95 % and a sensitivity of 82 % for the prediction of preeclampsia, as described by Elecsys (Roche). Methods: In this retrospective study the ratio of the prenatal antiangiogenic factor sFlt-1 (soluble fms-like tyrosine kinase-1) to the proangiogenic factor PIGF (placental growth factor) was analyzed using the electrochemiluminescence immunoassay of Elecsys (Roche Diagnostics, Mannheim, Germany) in 173 pregnant women. Sixty-three women with PE, 34 wo…
Design of antitumor drugs targeting c-kit receptor by a new mixed ligand-structure based method
2020
An important challenge, in the medicinal chemistry field, is the research of novel forceful drugs to overcome tumor-acquired resistance. The c-Kit tyrosine kinase receptor (TKR) represents a suitable target for the carcinogenesis control of gastro-intestinal stromal (GIST), leukemia, and mastocytosis tumors; nevertheless, several hotspot mutations of the protein limit the efficacy of a few clinical administered TKRs inhibitors. In this study, a new in silico protocol based on ligand and structure-based combined method is proposed, with the aim to identify a set of new c-Kit inhibitors able to complex c-Kit mutated proteins. A recent and freely available web-server DRUDIT is used for the lig…